Slob, a Slowpoke channel–binding protein, modulates synaptic transmission
نویسندگان
چکیده
منابع مشابه
Slob, a Slowpoke channel–binding protein, modulates synaptic transmission
Modulation of ion channels by regulatory proteins within the same macromolecular complex is a well-accepted concept, but the physiological consequences of such modulation are not fully understood. Slowpoke (Slo), a potassium channel critical for action potential repolarization and transmitter release, is regulated by Slo channel-binding protein (Slob), a Drosophila melanogaster Slo (dSlo) bindi...
متن کاملSLOB, a SLOWPOKE Channel Binding Protein, Regulates Insulin Pathway Signaling and Metabolism in Drosophila
There is ample evidence that ion channel modulation by accessory proteins within a macromolecular complex can regulate channel activity and thereby impact neuronal excitability. However, the downstream consequences of ion channel modulation remain largely undetermined. The Drosophila melanogaster large conductance calcium-activated potassium channel SLOWPOKE (SLO) undergoes modulation via its b...
متن کاملSlob, a Novel Protein that Interacts with the Slowpoke Calcium-Dependent Potassium Channel
Slob, a novel protein that binds to the carboxy-terminal domain of the Drosophila Slowpoke (dSlo) calcium-dependent potassium channel, was identified with a yeast two-hybrid screen. Slob and dSlo coimmunoprecipitate from Drosophila heads and heterologous host cells, suggesting that they interact in vivo. Slob also coimmunoprecipitates with the Drosophila EAG potassium channel but not with Droso...
متن کاملExpression and function of variants of Slob, Slowpoke channel binding protein, in Drosophila Abbreviated title: Variants of Slob in Drosophila
Slob binds to and modulates the Drosophila Slowpoke (dSlo) calcium-activated potassium channel, and also recruits the ubiquitous signaling protein 14-3-3 to the channel regulatory complex. RT-PCR reveals the presence of multiple slob transcripts in Drosophila heads. The transcripts are predicted to encode proteins that we call Slob51 (kDa), Slob57, Slob65 and Slob71. Slob51 and Slob65 are splic...
متن کاملThe Amino Terminus of Slob, Slowpoke Channel Binding Protein, Critically Influences Its Modulation of the Channel
The Drosophila Slowpoke calcium-dependent potassium channel (dSlo) binding protein Slob was discovered by a yeast two-hybrid screen using the carboxy-terminal tail region of dSlo as bait. Slob binds to and modulates the dSlo channel. We have found that there are several Slob proteins, resulting from multiple translational start sites and alternative splicing, and have named them based on their ...
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ژورنال
عنوان ژورنال: Journal of General Physiology
سال: 2011
ISSN: 1540-7748,0022-1295
DOI: 10.1085/jgp.201010439